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De to mest kjente endocannabinoide reseptorene er CB1 og CB2 reseptorer. CB1 reseptorer er i hovedsak mest tallrike i sentralnervesystemet mens CB2 reseptorer er mest tallrike perifert.I enda mer alvorlige tilfeller av isjias kan guy oppleve at det blir vanskelig å late vannet eller at person blir slapp i endetarmsåpningen i tillegg til nummenhet

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